Endocrine Abstracts

Prostate cancer cells show a variable expression of androgen receptor (AR). Its function is influenced by coregulatory proteins that may interact with the N-terminal and/or ligand-binding domain. Cofactor expression and function may be altered in prostate cancer. Studies by my group were focused on the transcriptional integrator CBP and its functional homologue p300 in prostate cancer. We found that CBP selectively potentiates activation of the AR by the non-steroidal anti-and...